中国科学院深圳先进技术研究院王枫等研究人员合作绘制出雌雄Shank3b小鼠的行为特征。相关论文于2024年6月20日在线发表在《神经科学通报》杂志上。

据悉，ASD以社交和重复性异常为特征。虽然Shank3b突变的ASD小鼠模型被广泛应用于ASD研究，但该模型的行为表型尚未完全阐明。

附：英文原文

Title: Mapping the Behavioral Signatures of Shank3b Mice in Both Sexes

Author: Liu, Jingjing, Ye, Jialin, Ji, Chunyuan, Ren, Wenting, He, Youwei, Xu, Fuqiang, Wang, Feng

Issue&Volume: 2024-06-20

Abstract: Autism spectrum disorders (ASD) are characterized by social and repetitive abnormalities. Although the ASD mouse model with Shank3b mutations is widely used in ASD research, the behavioral phenotype of this model has not been fully elucidated. Here, a 3D-motion capture system and linear discriminant analysis were used to comprehensively record and analyze the behavioral patterns of male and female Shank3b mutant mice. It was found that both sexes replicated the core and accompanied symptoms of ASD, with significant sex differences. Further, Shank3b heterozygous knockout mice exhibited distinct autistic behaviors, that were significantly different from those those observed in the wild type and homozygous knockout groups. Our findings provide evidence for the inclusion of both sexes and experimental approaches to efficiently characterize heterozygous transgenic models, which are more clinically relevant in autistic studies.

DOI: 10.1007/s12264-024-01237-8

Source: https://link.springer.com/article/10.1007/s12264-024-01237-8