中国科学院理化技术研究所葛介超-团队报道了用于长期光动力治疗肿瘤的可注射H₂O₂响应性聚合物点水凝胶。相关研究成果于2024年6月26日发表在国际顶尖学术期刊《中国高分子科学杂志》。

光动力疗法（PDT）已成为癌症治疗的一种很有前途的方式。然而，开发能够持续释放光敏剂（PSs）用于长期PDT治疗的药物递送系统仍然是一个挑战。

该文制备了一种H₂O₂响应性可注射水凝胶，该水凝胶由N1-（4-硼苄基）-N3-（4-硼苯基）-N1，N1，N3，N3-四甲基丙烷-1，3-二胺（TSPBA）与含有PVA的聚噻吩季铵盐（PT2）聚合物点（PDots）作为光敏剂共价交联。在H₂O₂的刺激下，获得的可注射水凝胶逐渐降解并释放PDots。

体外实验表明，释放的PDots在577nm激光照射下具有强大的单线态产氧能力，可以实现对肿瘤细胞的有效抑制。体内研究表明，单剂量给药后，PDots可持续滞留至少7天，在没有明显生物毒性的情况下，光照3次可促进有效的肿瘤抑制。

该项工作提出了一种创新的基于聚合物点的复合局部给药系统，用于癌症的长期PDT治疗。

附：英文原文

Title: H2O2-Responsive Injectable Polymer Dots Hydrogel for Long-term Photodynamic Therapy of Tumors

Author: Jian Wang, Ke Liang, Jian Li, Yun-Xiu Zhang, Xiao-Kuang Xue, Tie-Jin Chen, Yong-Liang Hao, Jia-Sheng Wu, Jie-Chao Ge

Issue&Volume: 2024-06-26

Abstract: Photodynamic therapy (PDT) has been emerged as a promising modality for cancer treatment. However, the development of drug delivery system enabling continuous release of photosensitizers (PSs) for long-term PDT treatment still remains challenges. Herein, a H2O2-responsive injectable hydrogel, covalently crosslinked by N1-(4-boronobenzyl)-N3-(4-boronophenyl)-N1,N1,N3,N3-tetramethylpropane-1,3-diaminium (TSPBA) with PVA containing polythiophene quaternary ammonium salt (PT2) polymer dots (PDots) as a photosensitizer was fabricated. Under the stimulation of H2O2, the obtained injectable hydrogel gradually degrades and releases PDots. In vitro experiments suggested that the released PDots could realize efficient tumor cells inhibition through its robust singlet oxygen generation capability upon 577 nm laser irradiation. In vivo studies demonstrated a sustained retention of PDots for at least 7 days following single-dose administration, facilitating efficient tumor inhibition with light treatments for 3 times without apparent biotoxicity. This work presents an innovative polymer dots-based composite local drug delivery system for long-term PDT in cancer treatment.

DOI: 10.1007/s10118-024-3155-z

Source: https://www.cjps.org/en/article/doi/10.1007/s10118-024-3155-z/