四川大学李涛等研究人员合作发现，乙酸能够在睡眠中断期间提升代谢适应性和认知表现。相关论文于2024年8月19日在线发表在《细胞—代谢》杂志上。

据介绍，睡眠对于整体健康至关重要，睡眠中断与代谢失调、认知功能受损和心血管疾病风险增加有关，但其分子机制尚不完全清楚。

附：英文原文

Title: Acetate enables metabolic fitness and cognitive performance during sleep disruption

Author: Qinqin He, Liwei Ji, Yanyan Wang, Yarong Zhang, Haiyan Wang, Junyan Wang, Qing Zhu, Maodi Xie, Wei Ou, Jun Liu, Kuo Tang, Kening Lu, Qingmei Liu, Jian Zhou, Rui Zhao, Xintian Cai, Nanfang Li, Yang Cao, Tao Li

Issue&Volume: 2024-08-19

Abstract: Sleep is essential for overall health, and its disruption is linked to increased risksof metabolic, cognitive, and cardiovascular dysfunctions; however, the molecular mechanismsremain poorly understood. This study investigated how sleep disturbances contributeto metabolic imbalance and cognition impairment using a chronic sleep fragmentation(SF) mouse model. SF mice exhibited impaired cognition, glucose metabolism, and insulinsensitivity compared with controls. We identified increased acetate levels in hypothalamicastrocytes as a defensive response in SF mice. Through acetate infusion or astrocyte-specificAcss1 deletion to elevate acetate levels, we observed mitigated metabolic and cognitiveimpairments in SF mice. Mechanistically, acetate binds and activates pyruvate carboxylase,thereby restoring glycolysis and the tricarboxylic acid cycle. Among individuals mostcommonly affected by SF, patients with obstructive sleep apnea exhibited elevatedacetate levels when coupled with type 2 diabetes. Our study uncovers the protectiveeffect of acetate against sleep-induced metabolic and cognitive impairments.

DOI: 10.1016/j.cmet.2024.07.019

Source: https://www.cell.com/cell-metabolism/abstract/S1550-4131(24)00290-0