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| 女锟皆诧拷锟剿癸拷锟斤拷锟斤拷锟斤拷锟斤拷锟絏锟斤拷锟斤拷影 |
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锟斤拷锟斤拷锟斤拷锟斤拷锟桔合帮拷症锟斤拷锟斤拷(NCCN)锟皆硷拷锟斤拷锟斤拷锟斤拷症学锟斤拷(ACS)锟饺碉拷锟劫达拷实锟斤拷指锟较撅拷锟狡硷拷锟斤拷锟斤拷为锟斤拷锟劫帮拷锟斤拷危锟斤拷群锟斤拷BRCA锟斤拷锟斤拷突锟斤拷女锟斤拷应锟斤拷25~30锟疥开始锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟絏锟斤拷锟斤拷影筛锟介。锟斤拷锟角ｏ拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷症锟叫撅拷锟斤拷锟斤拷志锟斤拷[J Natl Cancer Inst 2009锟斤拷101(3): 205]锟斤拷锟秸凤拷锟斤拷锟斤拷一篇锟斤拷锟侥称ｏ拷锟斤拷锟斤拷锟斤拷群锟斤拷筛锟斤拷锟斤拷始锟斤拷锟斤拷应锟斤拷锟斤拷锟斤拷35锟疥，锟斤拷锟节达拷锟斤拷锟斤拷筛锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷弑锟铰段ｏ拷锟斤拷锟斤拷锟缴革拷锟斤拷锟芥。锟叫癸拷医学锟斤拷学院锟斤拷锟斤拷医院锟斤拷锟斤拷咏锟斤拷锟斤拷诘锟斤拷锟斤拷锟斤拷芯锟绞敝革拷锟斤拷锟斤拷夜锟脚拷锟揭诧拷锟斤拷斯锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷X锟斤拷锟斤拷影筛锟介。
约锟斤拷斯·锟斤拷锟秸斤拷斯·锟斤拷隆锟斤拷锟今公癸拷锟斤拷锟斤拷学院锟侥德革拷锟斤拷锟斤拷斯(de Gonzalez)锟饺达拷前锟斤拷锟叫撅拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟劫帮拷锟斤拷锟斤拷史锟斤拷女锟皆ｏ拷40锟斤拷前锟斤拷锟斤拷X锟斤拷锟斤拷影筛锟斤拷锟斤拷娲︼拷锟斤拷锟斤拷薹锟斤拷锟斤拷锟斤拷锟斤拷锟轿ｏ拷铡锟斤拷锟斤拷锟斤拷锟紹RCA锟斤拷锟斤拷突锟斤拷锟竭ｏ拷锟斤拷然锟斤拷锟劫达拷实锟斤拷指锟斤拷锟狡硷拷锟斤拷锟斤拷25锟斤拷时锟酵匡拷始每锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷X锟斤拷锟斤拷影筛锟介，锟斤拷40锟斤拷前锟斤拷锟杰革拷筛锟斤拷陌锟饺拷院锟斤拷锟叫э拷锟斤拷锟轿达拷锟饺凤拷锟斤拷锟剿革拷锟斤拷群也锟斤拷锟斤拷锟斤拷锟狡碉拷锟斤拷锟斤拷:BRCA锟斤拷锟斤拷突锟斤拷锟斤拷锟斤拷锟�(<40锟斤拷)女锟斤拷每锟斤拷锟斤拷锟斤拷锟斤拷锟絏锟斤拷锟斤拷影筛锟介，锟斤拷锟斤拷锟秸碉拷锟斤拷锟劫帮拷锟斤拷锟斤拷危锟斤拷锟叫讹拷锟�?De Gonzalez锟斤拷也为锟斤拷锟劫次斤拷锟斤拷锟叫撅拷锟斤拷
为锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟秸碉拷锟斤拷锟劫帮拷危锟秸ｏ拷锟叫撅拷锟竭诧拷锟斤拷锟斤拷一锟街筹拷锟斤拷锟斤拷锟轿ｏ拷锟�(excess relatire risk)模锟酵ｏ拷锟斤拷模锟酵伙拷锟节伙拷锟杰凤拷锟斤拷(锟斤拷锟斤拷3锟斤拷锟斤拷锟叫★拷7600锟斤拷锟斤拷锟竭憋拷露锟斤拷)锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷BRCA1突锟斤拷锟竭ｏ拷25~29锟斤拷锟斤拷锟矫匡拷锟缴革拷榈硷拷碌锟斤拷锟斤拷锟斤拷盏锟斤拷锟斤拷侔锟斤拷锟斤拷锟斤拷锟斤拷锟轿ｏ拷锟轿�26/锟斤拷锟剿ｏ拷30~34锟斤拷锟斤拷锟缴革拷锟侥癸拷锟斤拷锟斤拷锟斤拷危锟斤拷为20/锟斤拷锟剿ｏ拷35~39锟斤拷锟斤拷锟缴革拷锟侥癸拷锟斤拷锟斤拷锟斤拷危锟斤拷为13/锟斤拷锟剿★拷锟斤拷要锟斤拷锟斤拷锟斤拷些危锟秸ｏ拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟缴革拷锟街憋拷锟斤拷要使锟斤拷锟劫帮拷锟斤拷锟斤拷锟绞斤拷锟斤拷51%锟斤拷12%锟斤拷4%锟斤拷BRCA2锟斤拷锟斤拷突锟斤拷锟斤拷锟斤拷然锟斤拷锟斤拷BRCA1锟斤拷锟斤拷为锟斤拷锟斤拷锟斤拷锟斤拷危锟斤拷锟借降锟酵碉拷锟斤拷锟劫帮拷锟斤拷锟斤拷锟绞癸拷锟狡凤拷锟斤拷锟斤拷锟狡★拷
锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷丫锟斤拷锟绞撅拷锟斤拷锟斤拷锟絏锟斤拷锟斤拷影筛锟斤拷锟绞�40~49锟斤拷锟轿Ｅ拷锟斤拷锟斤拷侔锟斤拷锟斤拷锟斤拷式锟斤拷锟�15%~25%锟斤拷锟斤拷锟斤拷锟斤拷些锟斤拷锟斤拷锟斤拷芯锟斤拷锟斤拷锟轿拷锟紹RCA锟斤拷锟斤拷突锟斤拷锟斤拷锟斤拷25~29锟斤拷锟斤拷锟缴革拷锟斤拷蘧锟斤拷锟斤拷妫�30~34锟斤拷锟斤拷锟缴革拷锟侥撅拷锟斤拷锟斤拷锟叫★拷锟街伙拷锟�35锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷筛锟斤拷锟斤拷锟揭伙拷锟斤拷木锟斤拷锟斤拷妗ｏ拷锟斤拷锟皆达拷锟斤拷泄锟揭窖э拷锟教筹拷锟� 锟斤拷锟斤拷楼锟斤拷
锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷症锟叫撅拷锟斤拷锟斤拷志锟斤拷锟斤拷
Journal of the National Cancer Institute锟斤拷锟斤拷doi:10.1093/jnci/djn440锟斤拷Amy Berrington de Gonzalez锟斤拷Mark Robson锟斤拷
