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锟斤拷锟斤拷Nature锟斤拷锟斤拷一系锟叫癸拷锟节帮拷症锟叫撅拷锟斤拷锟斤拷一些锟斤拷锟铰斤拷展锟斤拷锟叫撅拷锟斤拷锟侥猴拷锟斤拷锟斤拷锟斤拷锟铰★拷锟斤拷锟斤拷一篇锟斤拷锟斤拷锟斤拷锟铰回癸拷锟斤拷锟斤拷锟斤拷锟斤拷80锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟街拷糯锟窖э拷锟斤拷锟斤拷锟饺★拷玫慕锟秸癸拷锟秸癸拷锟斤拷私锟斤拷锟斤拷锟节帮拷症锟斤拷锟斤拷锟斤拷学锟斤拷锟斤拷锟斤拷芸锟斤拷锟斤拷慕锟秸癸拷锟斤拷锟狡拷锟斤拷姆直鸨ǜ锟斤拷斯锟斤拷锟斤拷锟绞筹拷桶锟街拷锟斤拷锟斤拷锟斤拷芯锟斤拷锟斤拷锟斤拷锟�“锟斤拷锟斤拷—锟斤拷锟斤拷酶锟斤拷”锟斤拷系锟叫碉拷一锟斤拷锟斤拷颖锟侥匡拷锟斤拷药锟斤拷锟斤拷锟斤拷目锟疥。Gao锟斤拷锟剿凤拷锟街ｏ拷Myc锟铰帮拷锟斤拷锟斤拷锟节很讹拷锟斤拷锟洁癌症锟叫凤拷锟斤拷突锟戒）锟斤拷一锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷酶锟侥憋拷锟斤拷锟斤拷锟揭拷锟轿NA锟斤拷锟截ｏ拷锟接讹拷锟节帮拷症锟斤拷锟叫恢拷浣拷锟斤拷锟斤拷锟揭伙拷锟斤拷锟较碉拷锟紿edgehog锟脚猴拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟诫几锟街帮拷症锟叫关ｏ拷锟斤拷锟斤拷锟斤拷Zhao锟斤拷锟剿凤拷锟街ｏ拷锟斤拷锟斤拷锟斤拷锟皆癸拷锟斤拷锟皆帮拷血锟斤拷锟斤拷维锟街帮拷血锟斤拷锟斤拷细锟斤拷锟侥达拷锟节★拷Diehn锟斤拷锟剿讹拷锟斤拷锟斤拷锟斤拷小锟斤拷锟斤拷锟劫帮拷锟叫的帮拷症锟斤拷细锟斤拷锟斤拷锟斤拷锟剿凤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷“锟斤拷锟斤拷锟斤拷”锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷细锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟绞癸拷锟斤拷锟斤拷侔锟斤拷锟街拷锟斤拷锟揭恍╋拷锟街拷苑锟斤拷撇锟教拷锟斤拷械锟揭伙拷锟斤拷锟斤拷亍锟斤拷锟斤拷诜锟斤拷锟轿伙拷锟斤拷锟斤拷侔锟较革拷锟斤拷锟�
锟斤拷症锟斤拷锟斤拷锟斤拷学时锟斤拷
锟斤拷1982锟斤拷HRAS锟斤拷锟斤拷突锟斤拷锟斤拷锟斤拷装锟街拷锟侥癸拷系锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟叫撅拷锟斤拷员锟窖撅拷锟节帮拷症锟斤拷锟斤拷锟斤拷锟较凤拷锟斤拷锟斤拷约10锟斤拷锟斤拷斐ｏ拷锟斤拷锟斤拷锟剿ｏ拷锟斤拷锟节帮拷症锟侥凤拷展锟斤拷锟斤拷锟窖撅拷知锟斤拷锟杰多，锟斤拷锟斤拷锟节帮拷症锟斤拷锟斤拷织锟斤拷锟斤拷锟斤拷锟斤拷锟街拷啵拷锟斤拷锟揭拷私锟侥讹拷锟斤拷锟斤拷锟杰讹拷芏唷ｏ拷锟斤拷冢锟斤拷锟斤拷糯锟斤拷模锟斤拷锟斤拷DNA锟斤拷锟斤拷锟斤拷锟侥凤拷展锟斤拷锟斤拷锟斤拷锟节计碉拷锟诫癌症锟斤拷氐锟酵伙拷锟杰快将锟斤拷锟斤拷锟街★拷锟斤拷一篇锟斤拷锟捷广泛锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟叫ｏ拷Michael Stratton锟斤拷Peter Campbell锟斤拷Andrew Futreal锟皆帮拷症锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷取锟矫的成就斤拷锟斤拷锟剿回顾ｏ拷同时展锟斤拷锟剿达拷锟斤拷锟斤拷症锟斤拷锟斤拷DNA锟斤拷锟叫的伙拷媒锟斤拷砂锟斤拷锟斤拷锟斤拷墙锟揭伙拷锟斤拷锟斤拷锟皆帮拷症锟斤拷锟狡凤拷锟斤拷之锟斤拷识锟斤拷前锟斤拷锟斤拷
锟斤拷食锟诫癌症锟侥癸拷系
锟斤拷锟斤拷知锟斤拷锟斤拷锟斤拷锟斤拷食锟斤拷锟斤拷锟斤拷锟洁动锟斤拷锟叫匡拷锟斤拷效锟斤拷锟斤拷锟叫硷拷十锟斤拷锟剿ｏ拷锟斤拷锟斤拷锟剿吃撅拷锟斤拷锟角ｏ拷锟斤拷锟角对撅拷锟斤拷某锟斤拷锟斤拷锟斤拷锟角凤拷锟皆斤拷食锟斤拷施锟斤拷锟斤拷锟斤拷应锟侥凤拷锟接伙拷锟斤拷却知之锟斤拷锟劫★拷Nada Kalaany锟斤拷David Sabatini锟斤拷锟芥，某些锟斤拷锟洁癌细锟斤拷系锟斤拷锟斤拷锟斤拷小锟斤拷锟斤拷锟斤拷锟斤拷为锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷植锟斤拷锟斤拷锟斤拷时锟斤拷锟斤拷锟斤拷锟斤拷食锟斤拷锟狡的匡拷锟斤拷锟斤拷效应锟角筹拷锟斤拷锟叫ｏ拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟较革拷锟较碉拷锟皆达拷锟叫抵匡拷锟斤拷锟斤拷锟斤拷锟节ｏ拷锟斤拷锟斤拷锟斤拷锟斤拷锟酵拷锟斤拷卸鹊锟皆拷锟斤拷驯锟斤拷锟斤拷锟斤拷锟�“phosphatidylinositol-3-kinase/Akt”锟脚猴拷通锟斤拷锟侥活化状态锟斤拷锟斤拷耍锟斤拷锟揭煌拷锟斤拷锟阶刺拷锟斤拷锟斤拷锟街甘撅拷锟叫╋拷锟斤拷锟斤拷锟斤拷模锟斤拷锟斤拷食锟斤拷锟狡碉拷锟斤拷锟狡凤拷锟斤拷锟斤拷锟斤拷锟斤拷应锟斤拷一锟斤拷指示锟斤拷锟斤拷
锟皆凤拷锟斤拷锟斤拷系为目锟斤拷锟�锟斤拷症锟斤拷锟狡凤拷锟斤拷
“锟斤拷锟斤拷—锟斤拷锟斤拷酶锟斤拷”锟斤拷系锟斤拷细锟斤拷锟节碉拷锟阶斤拷锟叫憋拷牵锟斤拷越锟斤拷浣碉拷狻ｏ拷锟斤拷呛芏锟较革拷锟斤拷锟斤拷艿牡锟斤拷鼗锟斤拷频墓锟斤拷刹锟斤拷郑锟斤拷锟斤拷锟揭恍╋拷锟斤拷锟斤拷氚┲拷泄亍锟斤拷锟斤拷冢锟斤拷锟斤拷锟矫革拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷诔锟轿拷锟斤拷锟斤拷锟揭╋拷铮拷锟斤拷械锟揭伙拷锟斤拷锟斤拷锟斤拷俅锟斤拷锟斤拷锟�“锟斤拷锟斤拷锟斤拷锟斤拷”锟斤拷锟斤拷锟斤拷锟斤拷锟狡讹拷锟街癸拷锟斤拷锟斤拷锟斤拷一些锟杰帮拷锟斤拷锟斤拷Soucy锟斤拷锟剿憋拷锟斤拷锟斤拷MLN4924锟侥凤拷锟街ｏ拷锟斤拷锟斤拷“NEDD8-锟斤拷锟斤拷酶”锟斤拷NAE锟斤拷锟斤拷一锟斤拷小锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟接ｏ拷目前锟斤拷锟节斤拷锟斤拷一锟斤拷锟劫达拷锟斤拷锟介。NAE锟斤拷锟斤拷“锟斤拷锟斤拷锟斤拷锟斤拷酶”一锟斤拷锟斤拷锟酵ｏ拷锟斤拷cullin-RING锟斤拷锟侥伙拷锟皆ｏ拷锟斤拷锟斤拷锟街匡拷锟狡革拷锟街诧拷同细锟斤拷锟斤拷锟阶的斤拷锟解。MLN4924锟斤拷小锟斤拷症模锟斤拷锟斤拷锟秸碉拷锟斤拷细锟斤拷锟斤拷锟斤拷锟酵诧拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟皆★拷
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“锟斤拷锟斤拷锟斤拷锟铰硷拷”锟角达拷约24锟斤拷锟斤拷前锟斤拷锟斤拷始锟节达拷锟斤拷锟叫伙拷锟斤拷时锟斤拷锟斤拷锟较碉拷一锟斤拷时锟节ｏ拷锟斤拷锟斤拷锟姐泛锟斤拷为锟斤拷锟缴达拷锟斤拷锟斤拷锟斤拷水平锟斤拷锟酵达拷锟斤拷锟侥★拷锟斤拷时锟斤拷什么使锟矫硷拷锟介开始锟斤拷失锟斤拷然锟斤拷确锟斤拷锟斤拷锟斤拷锟节ｏ拷锟斤拷锟节癸拷锟斤拷“锟斤拷锟斤拷状锟斤拷锟斤拷锟斤拷锟斤拷”锟斤拷锟斤拷锟斤拷约27锟斤拷锟斤拷前锟轿成的筹拷锟斤拷锟揭ｏ拷锟斤拷锟斤拷—锟斤拷锟斤拷锟接憋拷锟斤拷锟斤拷锟斤拷锟铰斤拷锟侥凤拷锟街ｏ拷Konhauser锟斤拷锟斤拷锟斤拷锟斤拷锟揭伙拷锟斤拷碌募锟斤拷锟斤拷锟斤拷锟斤拷图锟斤拷锟斤拷锟斤拷失锟斤拷锟斤拷锟角斤拷锟斤拷锟斤拷缺锟劫癸拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟侥硷拷锟劫ｏ拷锟斤拷锟斤拷锟街硷拷锟斤拷锟斤拷锟斤拷锟斤拷锟较诧拷锟斤拷锟铰度碉拷锟铰斤拷锟斤拷锟斤拷时锟斤拷锟斤拷锟斤拷锟斤拷“锟斤拷镁锟斤拷锟斤拷”锟界发锟斤拷锟侥硷拷锟劫★拷锟斤拷锟角诧拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟街的硷拷锟斤拷酶锟叫碉拷一锟斤拷锟截硷拷锟斤拷锟斤拷锟斤拷锟接ｏ拷锟斤拷锟斤拷锟戒含锟斤拷锟铰斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷远锟脚猴拷锟斤拷锟叫诧拷锟斤拷锟斤拷锟斤拷锟斤拷幕锟斤拷裕锟斤拷卸锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷募锟斤拷锟侥癸拷应锟斤拷
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