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4锟斤拷10锟秸ｏ拷锟斤拷锟斤拷权锟斤拷锟斤拷志锟斤拷锟斤拷学锟斤拷锟斤拷锟斤拷锟剿革拷锟斤拷锟斤拷学锟斤拷锟斤拷医学锟叫撅拷院锟斤拷跃锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟届导锟斤拷锟斤拷锟脚队碉拷锟叫撅拷锟缴癸拷——“锟今经斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷IDH1突锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷酶锟竭伙拷锟斤拷锟皆ｏ拷锟斤拷锟斤拷HIF1”锟斤拷锟斤拷一锟缴癸拷锟斤拷锟斤拷探锟斤拷锟剿伙拷锟斤拷突锟斤拷俳锟斤拷窬锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷姆锟斤拷踊锟斤拷锟斤拷锟斤拷业锟斤拷硕锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟叫э拷锟叫伙拷铮拷窬锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷拼锟斤拷锟斤拷碌锟斤拷锟解。
锟斤拷锟斤拷学锟斤拷为锟斤拷锟斤拷锟斤拷锟戒发锟斤拷锟斤拷锟斤拷锟斤拷锟铰ｏ拷锟皆该成癸拷锟斤拷锟斤拷锟剿高讹拷锟斤拷锟桔★拷锟斤拷锟斤拷学锟斤拷锟斤拷示锟矫成癸拷锟斤拷锟今经斤拷锟斤拷锟斤拷锟斤拷锟斤拷突锟斤拷锟斤拷踊锟斤拷锟斤拷慕锟绞撅拷锟斤拷锌锟斤拷锟斤拷锟斤拷锟斤拷澹拷锟斤拷锟斤拷锟酵拷锟斤拷锟斤拷(KG)锟斤拷锟斤拷锟斤拷园锟斤拷锟斤拷窬锟斤拷锟斤拷锟斤拷锟斤拷诘锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷卸锟斤拷锟斤拷锟斤拷茫锟轿拷俅锟斤拷锟斤拷锟揭╋拷锟侥匡拷锟斤拷锟揭碉拷锟斤拷一锟斤拷锟斤拷路锟斤拷
去锟斤拷10锟铰ｏ拷锟斤拷锟斤拷约锟斤拷锟斤拷锟秸斤拷斯锟斤拷学锟侥匡拷学锟斤拷锟节★拷锟斤拷学锟斤拷锟斤拷志锟斤拷锟斤拷锟叫撅拷锟斤拷锟侥ｏ拷锟斤拷锟街讹拷锟皆斤拷锟斤拷锟斤拷锟叫碉拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷酶1(IDH1)锟斤拷锟斤拷突锟戒，锟斤拷一锟斤拷锟窖革拷俦锟斤拷锟斤拷锟斤拷隙锟斤拷实锟斤拷锟斤拷锟节达拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷品锟斤拷确锟斤拷锟斤拷锟斤拷些锟叫撅拷锟斤拷锟斤拷锟斤拷IDH1锟斤拷锟斤拷突锟斤拷锟节继凤拷锟斤拷锟今经斤拷锟斤拷锟斤拷锟叫碉拷突锟斤拷频锟绞高达拷75%锟斤拷锟较ｏ拷使锟斤拷IDH1锟斤拷锟斤拷锟轿憋拷诘锟斤拷窬锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷指锟斤拷桶锟斤拷锟斤拷锟斤拷锟侥匡拷辍ｏ拷锟绞碉拷职锟斤拷锟斤拷锟斤拷频墓丶锟斤拷欠锟斤拷锟絀DH1锟斤拷锟斤拷突锟斤拷俳锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷幕锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷歉锟斤拷锟斤拷锟窖э拷锟斤拷锟揭窖э拷芯锟皆猴拷锟斤拷锟较革拷锟斤拷锟斤拷锟窖э拷芯锟斤拷锟�(锟斤拷锟斤拷MCB)锟斤拷锟斤拷锟脚讹拷锟斤拷锟斤拷锟斤拷锟截达拷锟阶★拷
锟斤拷锟斤拷MCB锟叫撅拷锟斤拷员锟教苦攻锟截ｏ拷锟杰快发锟街ｏ拷IDH1锟斤拷锟斤拷突锟斤拷锟斤拷锟斤拷锟较革拷锟斤拷锟絀DH1锟侥伙拷锟斤拷锟斤拷锟斤拷锟铰帮拷锟斤拷KG水平锟斤拷锟斤拷锟铰斤拷锟斤拷锟斤拷KG锟斤拷锟铰斤拷锟斤拷锟揭伙拷锟斤拷锟斤拷赂锟斤拷锟斤拷锟斤拷腔锟斤拷锟矫�(prolylhdroxylase)锟斤拷锟斤拷锟侥斤拷锟酵★拷锟铰凤拷锟狡碉拷锟剿讹拷锟斤拷诺锟斤拷锟斤拷一锟斤拷锟斤拷一系锟叫凤拷应锟斤拷锟斤拷锟斤拷细锟斤拷缺锟斤拷锟秸碉拷锟斤拷锟斤拷(HIF1)锟斤拷锟饺讹拷锟斤拷锟斤拷锟接ｏ拷锟接讹拷锟斤拷锟斤拷锟斤拷HIF锟脚猴拷通路锟斤拷锟斤拷锟秸促斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷
锟斤拷锟斤拷一锟斤拷锟斤拷锟叫ｏ拷IDH1锟斤拷锟斤拷突锟斤拷锟斤拷锟斤拷锟轿拷锟斤拷锟较革拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟揭伙拷锟斤拷锟斤拷牛锟斤拷锟斤拷锟斤拷锟組CB锟斤拷锟斤拷锟斤拷员却为锟斤拷锟斤拷锟斤拷锟斤拷细锟斤拷锟斤拷锟斤拷锟揭碉拷锟斤拷锟斤拷锟斤拷“刹锟斤拷”锟斤拷锟节凤拷锟斤拷锟今经斤拷锟斤拷锟斤拷锟斤拷锟斤拷突锟斤拷锟斤拷踊锟斤拷锟斤拷螅锟斤拷锟斤拷哦硬锟矫伙拷锟角筹拷锟斤拷锟街癸拷锟斤拷锟斤拷锟斤拷锟较诧拷胤锟斤拷郑锟揭伙拷锟斤拷锟斤拷诖锟叫伙拷锟終G锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟叫э拷锟斤拷锟紿IF1锟斤拷锟斤拷锟接ｏ拷锟斤拷锟斤拷锟斤拷锟斤拷裕锟斤拷潭锟斤拷锟街笻IF锟脚猴拷通路锟侥硷拷锟筋，锟斤拷锟斤拷锟斤拷细锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷一锟脚达拷锟斤拷刹锟斤拷锟斤拷值锟斤拷一锟斤拷锟斤拷牵锟斤拷锟斤拷锟終G锟斤拷锟斤拷锟斤拷锟角斤拷锟斤拷锟斤拷锟斤拷锟斤拷细锟斤拷锟节的达拷谢锟斤拷锟斤拷愿锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷薅锟斤拷锟斤拷锟斤拷煤锟斤拷懦锟斤拷锟斤拷锟斤拷旨锟斤拷捉锟斤拷锟较革拷锟斤拷锟斤拷芸锟斤拷锟斤拷应锟斤拷锟斤拷锟劫达拷锟斤拷为锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷药锟侥匡拷锟斤拷锟斤拷锟斤拷一锟斤拷锟铰的达拷锟节★拷
锟斤拷锟斤拷锟斤拷锟斤拷喜锟斤拷锟角ｏ拷锟斤拷锟斤拷HIF1锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟侥凤拷锟斤拷锟斤拷展锟斤拷锟斤拷锟斤拷锟斤拷要锟斤拷锟矫ｏ拷锟矫凤拷锟接伙拷锟斤拷锟侥凤拷锟斤拷也锟斤拷为锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟结供锟杰好的斤拷锟斤拷锟斤拷濉ｏ拷锟終G锟斤拷锟斤拷锟斤拷猿锟斤拷窬锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷同锟斤拷锟斤拷锟斤拷锟斤拷效锟斤拷锟斤拷锟狡猴拷锟斤拷锟斤拷锟斤拷锟矫★拷
锟斤拷锟斤拷锟剿癸拷锟斤拷某删锟斤拷锟角帮拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷指锟斤拷锟斤拷烁械锟斤拷锟斤拷龋锟斤拷锟斤拷锟斤拷锟皆逼斤拷锟斤拷锟斤拷锟街伙拷锟�30锟疥；锟脚队帮拷锟斤拷锟斤拷4锟斤拷锟斤拷师锟斤拷15锟斤拷锟叫撅拷锟斤拷锟斤拷3锟斤拷锟斤拷锟斤拷锟斤拷员锟斤拷1锟斤拷实锟斤拷锟揭癸拷锟斤拷锟斤拷员锟斤拷锟叫撅拷锟斤拷锟斤拷要锟斤拷锟斤拷锟斤拷锟斤拷锟疥级锟斤拷锟铰碉拷锟叫撅拷锟斤拷锟斤拷锟斤拷锟斤拷时6锟斤拷锟铰就成癸拷锟斤拷煽锟斤拷獠拷锟矫★拷锟斤拷学锟斤拷锟侥凤拷锟斤拷通知锟斤拷锟斤拷锟斤拷学锟斤拷锟斤拷志锟节短讹拷1锟斤拷锟斤拷锟节匡拷锟斤拷锟斤拷啥锟斤拷锟斤拷牡锟揭伙拷锟酵讹拷锟襟，革拷锟斤拷锟截碉拷选锟斤拷锟斤拷锟斤拷锟斤拷症锟叫撅拷协锟斤拷锟�100锟斤拷锟斤拷锟劫匡拷之前锟斤拷锟斤拷锟斤拷锟斤拷MCB指锟斤拷锟斤拷师之一锟斤拷群英锟斤拷锟杰ｏ拷锟斤拷锟斤拷锟斤拷锟斤拷学锟斤拷锟较凤拷锟斤拷锟斤拷锟斤拷篇锟斤拷锟铰ｏ拷锟斤拷支锟脚队斤拷锟斤拷锟铰份撅拷锟斤拷锟斤拷篇锟斤拷锟铰憋拷锟斤拷同锟侥癸拷锟斤拷锟斤拷锟斤拷锟斤拷志锟斤拷锟杰★拷锟斤拷锟斤拷源锟斤拷锟侥汇报锟斤拷
锟斤拷锟斤拷锟斤拷学锟斤拷锟斤拷
Science锟斤拷锟斤拷DOI: 10.1126/science.1170944锟斤拷Shimin Zhao锟斤拷Yue Xiong锟斤拷
锟斤拷锟斤拷锟侥讹拷锟斤拷英锟侥ｏ拷
锟斤拷锟斤拷学锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷摘要
