|
|
| Nestin锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟叫撅拷锟斤拷展 |
|
1锟斤拷15锟秸ｏ拷锟斤拷锟斤拷锟节匡拷锟斤拷锟斤拷锟斤化学锟斤拷志锟斤拷(JBC) 锟斤拷锟竭凤拷锟斤拷锟斤拷锟叫匡拷院锟较猴拷锟斤拷锟斤拷院锟斤拷锟斤拷锟斤拷细锟斤拷锟斤拷锟斤拷锟剿猴拷锟叫撅拷锟介及锟斤拷锟斤拷平锟叫撅拷锟斤拷锟斤拷Nestin锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟叫撅拷锟斤拷一锟斤拷锟铰凤拷锟街★拷
锟斤拷锟斤拷锟斤拷锟斤拷锟节凤拷锟斤拷锟斤拷锟斤拷锟叫ｏ拷锟斤拷锟斤拷锟斤拷系统锟斤拷锟斤拷锟斤拷一锟斤拷锟斤拷要锟铰硷拷锟斤拷Nestin锟斤拷一锟斤拷锟叫碉拷锟斤拷维锟斤拷锟阶ｏ拷锟斤拷锟节诧拷锟介动锟斤拷锟斤拷前锟斤拷细锟斤拷锟叫高憋拷锟斤，锟窖憋拷锟姐泛锟斤拷锟斤拷锟斤拷前锟斤拷细锟斤拷锟侥憋拷志锟斤拷锟接★拷锟叫撅拷Nestin锟斤拷锟斤拷谋锟斤拷锟斤拷锟截癸拷锟缴ｏ拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷识锟斤拷前锟斤拷细锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟皆★拷Nestin锟斤拷锟斤拷牡诙锟斤拷诤锟斤拷泳锟斤拷锟斤拷锟斤拷锟斤拷锟较低筹拷锟紺entral nervous system, CNS锟斤拷锟斤拷织锟斤拷锟斤拷锟斤拷锟斤拷强锟接伙拷锟皆ｏ拷然锟斤拷锟斤拷锟截该伙拷锟斤拷锟斤拷锟今经凤拷锟斤拷锟斤拷锟斤拷锟叫憋拷锟斤拷锟阶硷拷锟斤拷锟斤拷胁锟斤拷锟饺凤拷锟斤拷锟斤拷锟斤拷罟わ拷锟斤拷校锟斤拷锟街撅拷盏锟斤拷芯锟斤拷锟皆憋拷锟斤拷确锟斤拷锟叫★拷锟絅estin 锟斤拷锟斤拷牡诙锟斤拷锟斤拷诤锟斤拷锟斤拷锟街革拷锟斤拷锟斤拷锟斤拷锟斤拷LacZ锟节凤拷锟斤拷锟斤拷锟斤拷系统锟斤拷专一锟斤拷锟斤。锟斤拷锟竭碉拷转锟斤拷转锟斤拷锟斤拷小锟斤拷实锟斤拷锟揭伙拷锟街な碉拷锟叫★拷锟絅estin锟斤拷锟斤拷牡诙锟斤拷诤锟斤拷雍锟斤拷锟斤拷锟斤拷锟斤拷锟街革拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷胎锟斤拷锟斤拷锟叫碉拷CNS锟斤拷锟斤拷锟斤拷铩ｏ拷锟斤拷锟斤拷踊锟斤拷幔≧etinoic acid, RA锟斤拷锟秸碉拷锟斤拷P19细锟斤拷锟斤拷锟斤拷锟今经分伙拷模锟酵ｏ拷锟叫撅拷锟竭凤拷锟斤拷小锟斤拷Nestin锟斤拷锟斤拷锟斤拷锟今经分伙拷锟斤拷锟斤拷锟斤拷瞬时锟较碉拷锟斤拷锟斤拷一锟斤拷锟斤拷浠拷艿锟斤拷诙锟斤拷诤锟斤拷锟斤拷锟斤拷锟街拷锟斤拷锟斤拷锟斤拷锟角匡拷拥牡锟斤拷亍锟斤拷锟斤拷锟角匡拷拥幕锟斤拷锟斤拷锟轿达拷盏锟斤拷锟絇19EC细锟斤拷锟斤拷锟斤拷要锟斤拷锟斤拷锟斤拷Sox锟斤拷POU锟斤拷HRE锟斤拷SF1位锟姐，锟斤拷锟斤拷P19锟斤拷前锟斤拷细锟斤拷锟斤拷锟斤拷要锟斤拷锟斤拷锟斤拷Sox锟斤拷POU锟斤拷HRE位锟姐。锟斤拷一锟斤拷实锟斤拷锟斤拷锟斤拷锟阶硷拷锟斤拷锟絊ox2锟斤拷SF1锟介导Nestin锟斤拷锟斤拷锟斤拷未锟街伙拷锟斤拷P19细锟斤拷锟叫憋拷锟斤，锟斤拷转录锟斤拷锟斤拷Sox2锟斤拷Brn1锟斤拷Brn2锟斤拷锟斤拷Nestin锟斤拷锟斤拷锟斤拷P19锟斤拷前锟斤拷细锟斤拷锟叫憋拷锟斤。锟斤拷趣锟斤拷锟角ｏ拷锟叫撅拷锟竭凤拷锟斤拷锟斤拷小锟斤拷锟斤拷胎锟斤拷P19细锟斤拷锟今经分伙拷锟侥诧拷同时锟节ｏ拷POU锟斤拷锟斤拷牟锟酵拷锟皆蓖拷锟絇OU锟斤拷锟接斤拷锟轿伙拷锟斤拷锟斤拷锟斤拷Nestin锟斤拷锟斤拷谋锟斤拷铮拷锟斤拷锟斤拷锟教piblast锟斤拷未锟秸碉拷锟斤拷P19EC细锟斤拷锟叫ｏ拷Oct1 锟斤拷Oct4 锟斤拷锟斤拷锟絇OU位锟姐，锟斤拷锟斤拷锟斤拷胎锟斤拷P19锟斤拷前锟斤拷细锟斤拷锟叫ｏ拷Brn1锟斤拷Brn2锟斤拷锟轿伙拷锟斤拷稀锟�
锟斤拷些锟斤拷锟斤拷锟斤拷锟斤拷瞬锟酵硷拷锟斤拷拥锟绞憋拷锟斤拷锟较撅拷锟斤拷Nestin锟斤拷锟斤拷锟斤拷锟斤拷锟铰伙拷锟狡ｏ拷锟斤拷亟锟斤拷岣伙拷锟斤拷嵌锟斤拷锟角帮拷锟较革拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷缘锟斤拷锟绞讹拷锟斤拷锟斤拷锟皆达拷锟斤拷锌锟皆猴拷虾锟斤拷锟斤拷锟皆猴拷锟斤拷锟斤拷锟较革拷锟斤拷锟斤拷锟�
锟斤拷锟斤拷锟斤拷锟斤化学锟斤拷志锟斤拷(
JBC) 锟斤拷DOI: 10.1074/jbc.M805632200锟斤拷Naihe Jing锟斤拷Leping Cheng锟斤拷
